Sankar Surendran Selected Research

aspartoacylase

12/2010	Upregulation of N-acetylaspartic acid resulting nitric oxide toxicity induces aspartoacylase mutations and protein interaction to cause pathophysiology seen in Canavan disease.
4/2007	Absence-like and tonic seizures in aspartoacylase/attractin double-mutant mice.
7/2006	Upregulation of aspartoacylase activity in the duodenum of obesity induced diabetes mouse: implications on diabetic neuropathy.
1/2006	Canavan disease: studies on the knockout mouse.
7/2005	Aspartoacylase gene knockout in the mouse: impact on reproduction.
8/2004	Aspartoacylase deficiency does not affect N-acetylaspartylglutamate level or glutamate carboxypeptidase II activity in the knockout mouse brain.
9/2003	Canavan disease: a monogenic trait with complex genomic interaction.
5/2003	Adeno-associated virus-mediated aspartoacylase gene transfer to the brain of knockout mouse for canavan disease.

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Sankar Surendran Research Topics

Disease

10	Canavan Disease (Leukodystrophy, Spongiform) 12/2010 - 05/2003
8	Phenylketonurias (Phenylketonuria) 01/2007 - 12/2003
3	Parkinson Disease (Parkinson's Disease) 10/2010 - 04/2009
2	Neurodegenerative Diseases (Neurodegenerative Disease) 10/2010 - 10/2004
2	Obesity 07/2006 - 12/2005
1	Body Weight (Weight, Body) 09/2009
1	Gastrointestinal Diseases (Functional Gastrointestinal Disorders) 01/2009
1	Inflammation (Inflammations) 01/2009
1	Type 2 Diabetes Mellitus (MODY) 01/2009
1	Wounds and Injuries (Trauma) 09/2008
1	Seizures (Absence Seizure) 04/2007
1	Gastroparesis 01/2007
1	Glycogen Storage Disease Type II (Pompe's Disease) 11/2006
1	Glycogen Storage Disease (Glycogenosis) 11/2006
1	Diabetic Neuropathies (Diabetic Neuropathy) 07/2006
1	Disease Progression 11/2003
1	Megalencephaly 11/2003
1	Deafness (Deaf Mutism) 12/2002
1	Digitorenocerebral Syndrome 12/2002

Drug/Important Bio-Agent (IBA)

8	aspartoacylaseIBA 12/2010 - 05/2003
7	N-acetylaspartate (N-acetyl aspartate)IBA 12/2010 - 09/2003
5	EnzymesIBA 01/2009 - 11/2004
4	Amino Acids FDA Link 01/2007 - 08/2004
4	Phenylalanine Hydroxylase (Phenylalanine 4 Monooxygenase)IBA 06/2005 - 01/2004
3	Phenylalanine (L-Phenylalanine)FDA Link 06/2005 - 12/2003
2	Proteins (Proteins, Gene)FDA Link 12/2010 - 01/2009
2	CatecholaminesIBA 10/2010 - 09/2009
2	sapropterin (tetrahydrobiopterin)FDA Link 01/2007 - 11/2004
2	Nitric Oxide Synthase Type I (Neuronal Nitric Oxide Synthase)IBA 01/2007 - 12/2005
2	OrexinsIBA 04/2004 - 12/2003
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 12/2010
1	Pharmaceutical PreparationsIBA 09/2009
1	3,4-Dihydroxyphenylacetic AcidIBA 09/2009
1	Thiobarbituric Acid Reactive SubstancesIBA 09/2009
1	AshwagandhaIBA 04/2009
1	1- hydroxy- 2- oxo- 3,3- bis(2- aminoethyl)- 1- triazeneIBA 09/2008
1	GlucosidasesIBA 11/2006
1	AcidsIBA 11/2006
1	Hyaluronoglucosaminidase (Hyaluronidase)FDA Link 11/2006
1	alpha-Glucosidases (Acid Maltase)IBA 11/2006
1	trabecular meshwork-induced glucocorticoid response proteinIBA 07/2005
1	calpastatinIBA 06/2005
1	Acetates (Acetic Acid Esters)FDA Link 04/2005
1	Aspartic Acid (Aspartate)FDA Link 04/2005
1	NeuropeptidesIBA 08/2004
1	Glutamate Carboxypeptidase II (N-Acetylaspartylglutamate Peptidase)IBA 08/2004
1	isospaglumic acid (NAAGA)IBA 08/2004
1	BiopterinsIBA 01/2004
1	CreatinineIBA 11/2003
1	ProteomeIBA 09/2003
1	Amino Acid Transport System X-AG (Glutamate Transporter)IBA 08/2003
1	Serine Proteinase Inhibitors (Serine Protease Inhibitors)IBA 08/2003
1	gamma-Aminobutyric Acid (GABA)IBA 08/2003
1	Glutamic Acid (Glutamate)FDA Link 08/2003
1	Biomarkers (Surrogate Marker)IBA 12/2002
1	Ketoglutaric Acids (Ketoglutaric Acid)IBA 12/2002
1	Ketoglutarate Dehydrogenase Complex (Oxoglutarate Dehydrogenase)IBA 12/2002

Therapy/Procedure

1	Enzyme Replacement Therapy 11/2006
1	Oral Administration 11/2004
1	Transplantation 10/2004
1	Enzyme Therapy 08/2004